核心技术

ChemoPower专利技术: 混合物全成分分析领域权威

高效全成分分析是时代的需求

混合物并不是生涩的科学词汇，我们吃的食物、喝的水和使用的物品，都是以混合物形式存在于我们身边。因此，了解混合物的化学成分，特别是含有未知成分的复杂混合物的成分，可以为科研工作者提供宝贵的信息，我们可以用来研发更好的产品，或通过这些信息确保产品的质量和安全。化学成分分析的重要性是不可低估的。当2015年诺贝尔奖获得者屠呦呦女士认识到氯喹或奎宁的传统药物疗效不佳，努力寻找消灭疟疾的新方法时，她就是通过混合物成分分析，在传统草药这种可能是最复杂的混合物里以寻找可能的有效成分。屠女士设法分离和提取出青蒿的活性成分“青蒿素”，并证明这种当时的未知物对感染动物和人类的疟原虫有很强的杀灭作用。青蒿素这种中药材里发现的新型抗疟药物，为人类消灭疟疾，减轻疾病痛苦做出了极大的贡献。

现有技术

质谱分析法是一种用于鉴别混合物中化学成分的常用技术。然而，对于质谱法，具有相似物化性质的化合物往往以共洗脱的形式出现在质谱中，代表几种物质的谱图混合在一起无法区分，学界称之为“共流峰”。这使得科研人员很难区分这些相似的单个化合物，除非对样品进行复杂且昂贵的预处理，用物理方法先行分离相似化合物。预处理通常要求操作人员非常专业，并具有化学动力学等扎实的知识基础。此外，如果没有可用于分析数据的先验信息，当前的技术不能为未知混合物的成分准确定性。一般来说，质谱分析法要得出优秀的结果，要依仗有经验的科学家，在前辈的实验数据基础上设计详细的策略去识别未知化合物；如果没有这样的条件，面对复杂的共流峰，研究人员只能选择忽略这些成分。

ChemoPower’s Solution: Online Chemical Analysis System (patented)

To this end, ChemoPower developed a software which uses mathematical models to reconstruct pure components’ spectra and its concentration without prior information, using solely experimental data without any simulation or peak matching. This enables us to rapidly and digitally differentiate the individual peaks of the compounds that appeared co-eluted in the results. Our solution is built on the foundation of chemometrics: mathematical techniques based on statistics and optimization method to find local/global optima of a system and is crystallized from the knowledge of 200+ International Journals on chemometrics related algorithms. The founding team was awarded the Gold Award for the High Performance Computing (HPC) Quest 2003 in Singapore, hosted by IBM.

Advantages of Our Online Chemical Analysis System (OCAS):

By using OCAS, users worldwide can upload their experimental data onto OCAS and receive a report of our analysis via a few clicks of the mouse. Users can find pure components and their respective concentrations from the mixture peaks, which were either unable to be analyzed by current technology or very costly and time consuming to do so.

  • Time Savings: Time required to obtain the separated peaks is reduced by up to 100 times.
  • Enhanced Capabilities: Allows users to identify unknown components in mixtures without any a priori information which the existing methods are incapable of.
  • Simplify Processes: The software simplifies and automates the analysis process such that results can be obtained by a few clicks of the mouse.
  • Universal Compatibility: The software can process data obtained from GC-MS or LC-MS from across 7 major brands.
  • Available on Cloud, 24/7: Due to the elimination the need for physical separation of the chemical compounds, anyone can obtain the chemical analysis results anytime, anywhere by accessing our online system.
  • Cost Savings: Our software complements inexpensive equipment to produce high quality results and thus eliminates the need to purchase expensive equipment, resulting in low cost of running the equipment for chemical analysis. Furthermore, as our software is intuitive and simple to use, there is no need to hire highly qualified professionals to conduct the chemical analysis. Instead, anyone with basic equipment knowledge will be able to do the job just as well.

Areas of Application:

The principles of Technology are universally compatible with existing equipment and is fundamental to any industry which needs to identify chemical compounds within a mixture, such as Traditional Medicine, Food, Cosmetic, Environment and Pharmaceutical.